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Hydroperoxides disrupt membrane architecture, produce reactive aldehydes, and drive cell death 16

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Inflamed gastrointestinal lining will impair nutrient and thyroid absorption, thus leading to nutrient deficiencies and possibly even thyroid hormone deficiency due to impaired absorption

However, it should be noted that current evidence regarding amino acid metabolism-mediated regulation of macrophage polarization is derived mainly from in vitro macrophage models and animal experiments, whereas systematic validation in human diseases remains relatively limited

10.1016/j.pan.2017.03.006 5 Al-KhayriJ