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Wu J, Wang Y, Jiang R, Xue R, Yin X, Wu M, Meng Q
In vivo and in vitro models, it was found that in the IDH1 mutant glioma cells intervened by triptolide, the transcriptional activity of Nrf2 was suppressed, and the expression of genes related to glutathione anabolic metabolism (GCLC, GCLM, and SLC7A11) was significantly down-regulated
This study is notable because it used human cells (not mouse cells), providing evidence that FOXO4-DRI's mechanism functions in human biology at least in a cell culture context
It works just as a progesterone or estrogen cream would work, absorbing through your skin into your bloodstream
Although IF is linked to processes like autophagy, hormonal changes, and enhanced insulin sensitivity, the exact biological mechanisms that make IF safe and work are not fully understood
