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The authors also noted that further optimisation was needed, including work relating to high clearance in mice and off-target activity against monoamine oxidase A
5-Amino-1MQ is commonly studied in research settings for its interaction with metabolic pathways, particularly in relation to NNMT (Nicotinamide N-methyltransferase) activity, cellular energy regulation, and adipose tissue function
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Preclinical toxicological data: Acute and subacute toxicity studies in rats did not reveal any mortality or significant organ toxicity, even at doses well above therapeutic doses (up to 100 times the effective dose)
Kraus D, et al
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