In particular, compared to the mild degeneration group, the expression levels of ferroptosis driver genes ( ACSL4 , SLC39A14 , and CHAC1 ) were relatively higher in the severe degeneration group, whereas the expression levels of ferroptosis suppressor genes ( GPX4 , FTH1 , and HSPB1 ) were significantly lower (Fig
These reveal a potential mechanism by which DHA ameliorates liver fibrosis or PLC, and moreover suggest that ferroptosis is a favorable method to eliminate activated HSC or PLC cells
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