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Most critically, the paucity of pediatric-specific evidence cannot be overemphasized: the existing literature consists almost exclusively of case reports, with no completed RCTs specifically enrolling children with MC4R deficiency

That determination belongs to the licensed provider, not the platform

On physical exam, the patient had multiple 1-2 cm erythematous, scaly plaques located on the back, chest, and legs, some were excoriated with hemorrhagic crust (Figure 1)