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A case report published in the Journal of Clinical Endocrinology and Metabolism documented fatal, fulminant, necrotizing pancreatitis associated with recent tirzepatide initiation

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Proteins with similar partial sequence motifs PPPGKPQ- and PPPGKP- are present in proline rich (PRP) salivary protein group

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4 Departments of Medicine, Pediatrics, Ob/Gyn MFM and Biomedical Sciences, The Pennsylvania State University, Hershey, PA, United States, and Vinmec International Hospital, Times City, Hanoi, Vietnam

These drugs work by mimicking the action of naturally occurring GLP-1, an incretin hormone that stimulates insulin secretion in response to food intake, suppresses glucagon release, and slows gastric emptying