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Patients 2 years of age who responded to sepiapterin (n=114), defined as 15% reduction in blood phenylalanine levels, proceeded to Part 2 of the study

Study Design: A randomized, double-blind, placebo-controlled, 13 week trial was conducted, involving 125 obese (BMI 30 kg/m ) or overweight patients with metabolic complications (BMI 27 kg/m )

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5.2 CUL5 mediates the specific degradation of aberrant translation products Okumura et al

Avoid greasy breakfast meats (bacon, pork sausage), fried foods (hash browns, fried eggs), very high-fat options (croissants, biscuits with gravy), sugary pastries, and heavy cream-based dishes