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At that point, she called off work and mostly stayed in bed feeling sick

For tirzepatide versus semaglutide, contrary to the primary endpoint in the head-to-head comparison, there was some supporting evidence for tirzepatide to have a modest benefit, although the 95% CI overlapped the null (HR 0.91, 95% CI 0.81 to 1.01) (Fig

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But be aware that some people may experience gut issues when they consume too much (more than 1015g)