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Oxidative stress and zinc/copper homeostasis in MASLD The development of human MASLD is thought to be closely linked to increased oxidative stress, with Cu/Zn-SOD being one of the enzymes that counteract this stress

Phase II detoxification is the process by which the glutathione glutathione binds to xenobiotics (toxins, drugs, pollutants) via the enzyme glutathione-S-transferase (GST)

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Its relevance to women's health crystallised with the finding that MOTS-c levels decline with age and estrogen depletion correlating directly with reduced skeletal muscle insulin sensitivity and visceral adiposity in postmenopausal women