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High alcohol consumption activates microglia and dramatically increases ROS production (Qin and Crews, 2012), which can, in extreme situations, affect the fluidity of the mitochondrial membrane, resulting in functional changes and an increase in oxidant production (Haorah et al., 2011)

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[3] The water itself simply serves as a solvent or vehicle for the drug and does not alter the drugs mechanism of action

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When administering a higher dose, the benefits should be weighed against the risks