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These results come from brand-name semaglutide (Wegovy) without B12

(3) Disruption of membrane integrity: -syn interacts with the Translocase of the Outer Mitochondrial Membrane (TOM) complex (e.g., TOM40, TOM20) and the Voltage-Dependent Anion-Selective Channel 1 (VDAC1), which leads to abnormal membrane permeability (McCarthy et al., 2022)

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Clinical trials demonstrate sustained 210 fold increases in GH and 1.53 fold increases in IGF-1, with elevated IGF-1 persisting for up to 28 days after multiple doses [3]

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