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Step 5: Then and only then consider a gradual dose increase

Semaglutide is not approved for osteoarthritis, but findings like these are prompting rheumatologists and orthopedic surgeons to rethink how we manage knee disease before resorting to joint replacement

Consistent timing helps you predict and manage side effects

When to seek medical advice : Contact your GP or diabetes specialist promptly if you experience: Severe, persistent vomiting or diarrhoea leading to dehydration Severe abdominal pain, particularly if radiating to the back (potential pancreatitis) Signs of hypoglycaemia (if taking insulin or sulphonylureas concurrently) Symptoms of gallbladder problems (pain in the upper right abdomen, fever, yellowing of skin) Any changes in vision (rapid improvement in blood glucose can sometimes worsen diabetic retinopathy) [20] Unexplained persistent nausea beyond the first few weeks If you are planning pregnancy, discuss this with your healthcare provider as GLP-1 RAs are not recommended during pregnancy or breastfeeding

Tracking Your Progress One beneficial approach is to document your progress after each dosage adjustment