The behavioral test indicated amelioration of depressive-like symptoms in mice
Can glutathione keep you awake at night
Smythies J, De Iuliis A, Zanatta L, Galzigna L: The biochemical basis of Parkinson's disease: the role of catecholamine o-quinones: a review-discussion
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The link between GSTs and the MAP kinase pathway provides a rationale as to why in many cases the drugs used to select for resistance are neither subject to conjugation with GSH, nor substrates for GSTs
Interestingly, as shown in our transcriptome data, in addition to the pronounced enrichment of genes associated with JA signaling in systemic leaf tissues after GSH treatment, genes responsive to other defense phytohormones such as ethylene and salicylic acid, which are responsible for plant resistance to pathogen infection, are also highly upregulated (Supplementary Data 1), implying that GSH might also act as a signaling molecule to activate the plant systemic immune response