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Mechanistically, resmetirom enhances hepatic lipid oxidation, rapidly reduces liver fat content, and modulates intrahepatic metabolic and fibrogenic pathways, with relatively modest effects on body weight [20,21]

The mean (standard deviation) age of the cohort was 56 (10.6) years, with a mean duration of diabetes of 7.4 (5.7) years, mean HbA1c of 8.2 (0.9)% [66.1 (10.1) mmol/mol], and mean body mass index (BMI) of 33.5 (6.8) kg/m 2

NAD(+) metabolism: a therapeutic target for age-related metabolic disease