Documented Long-Term Side Effects of NSAIDs Regular or long-term NSAID use has been associated with: Damage to the gut lining, increasing intestinal permeability (leaky gut) and immune activation (27,29,31) Reduced absorption of key nutrients, including iron, folate, and vitamin C (28,29) Delayed tissue repair , particularly in connective tissue where prostaglandins are required for healing (32) Kidney stress and electrolyte imbalance , especially during dehydration or endurance activity (30) Increased cardiovascular risk , particularly with higher doses or prolonged exposure (30) These effects help explain why NSAIDs may temporarily reduce pain while progressively impairing healing capacity, increasing systemic inflammation, and slowing long-term recovery
Of note, cartilage created by FOXO4-DRI pretreated chondrocytes displays a lower senescence level than that from the untreated counterparts
Vuletic, L
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Dosage Adjustments for Special Populations Patients who are older, have kidney or liver issues, or have certain neurological disorders might need changes in their medication dosage amounts
Allergies to sulfonamide antibiotics and sulfur-containing drugs
