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Notably, there was no difference in the TNF protein expression of between BRCA and normal tissues in TCGA database, which possibly due to the abnormal expression of TNF in physiological or pathological states such as the inflammatory response and immune regulation 47

DNA damage repair: PARP1 consumes NAD+ to detect and repair DNA strand breaks

The dotted lines indicate protein-protein interactions (PPIs), while solid green lines represent interactions between proteins and metabolites (PMIs)

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However, they said more research is needed to better understand why GLP-1 drugs might help sleep apnea patients, and to track the potential longer-term benefits