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Reactive oxygen species (ROS) serve as a common initiator of the apoptotic process (Mats 2000)

Its role in mitochondrial function also contributes to improved cellular energy output

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IL-23-induced synovial inflammation is primarily linked to the activation of JAK-STAT, tyrosine kinase 2, NF-B, and retinoic acid receptor-related orphan receptors (RORs) (80)

One of the factors to consider is what other prescription medications, over-the-counter meds, and supplements are taken