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[2,9] This connection between gut-derived peptides and neurological function is an active area of investigation

Wang L et al

Goldstone A

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This common concern affects many patients using this GLP-1 receptor agonist for diabetes or weight management

The article says naltrexone blocks opioid receptors in the hypothalamus, removing inhibition of pro-opiomelanocortin neurons that regulate satiety, while bupropion is a norepinephrine-dopamine reuptake inhibitor that increases alertness and reduces appetite by raising dopamine and norepinephrine in the brain's appetite-control centres