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Tzang 2025 (18 RCTs): overweight/obesity regains +5.63 kg while type 2 diabetes regains +2.03 kg but rebounds harder on blood-sugar control (HbA1c +0.65 vs +0.25%)

Importantly, as blood glucose levels dropped, so too did the ability of GLP-1 to stimulate further insulin releaselimiting the potential for dangerous hypoglycemia (drop in blood glucose)

Gradual dose escalation and eating smaller, less fatty meals help minimize this side effect

It remains an investigational drug undergoing clinical trials, and there is no legitimate supply route outside of authorised research settings

A plateau can happen even when the medication is still active A plateau happens when weight stays about the same for a period of time despite continuing treatment

This unique mechanism opens doors for exploring treatments in metabolic disorders and tissue regeneration