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The creation of thousands of tiny holes dramatically increases the ability of active ingredients to pass through the stratum corneum (the thin layer of skin composed of already dead skin cells that functions as a barrier) and reach the epidermis where the active ingredients are needed

Lillys phase 2 retatrutide trial achieved up to 17.5% mean weight reduction at 24 weeks

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Compounded semaglutide is a non-FDA-approved preparation