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Some have proposed that ammonia is converted to glutamine, which causes cerebral edema either directly by its osmotic effect 37,38 or indirectly by decreasing other osmolytes, thereby promoting water retention

Medication gets left at home

It promotes growth, leading to swelling in joints and tissues

This may elevate the risk of developing metabolic syndrome or type 2 diabetes , especially with prolonged or excessive use (Schafer et al., 2002, Trends in Endocrinology & Metabolism )

Additionally, AQP9 deficiency leads to impaired glycogen synthesis, evidenced by increased levels of phosphorylated glycogen synthase (GS)

Diabetologia 66 , 17651779