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modulates matrix metalloproteinase activity

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Treatment with defactinib showed an increase in FAK, paxillin, and dual FAK-paxillin containing focal adhesions from 0.1 to 3.1 M, but at higher doses, defactinib was able to reduce the amount of FAK and paxillin containing FAs with an IC 50 value of 11.11 M and 18.65 M respectively (Fig