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This process is dependent on the upregulation of the SNAIL1 protein and the activation of extracellular signal-regulated kinase (ERK) 2 [91], whereas high expression of Sirtuin 6 (SIRT6) increases hypoxia-inducible factor-1 (HIF-1) to regulate the expression of both SNAIL and TWIST

Figure 1 A major conceptual advance in lactate biology was the discovery of protein lactylation, a novel post-translational modification directly derived from lactate metabolism (Vander Heiden et al., 2009)

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