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The LRR17 and LRR18 loops are in a similar position in the crystallographic ASK1 Os D3 At D14 complex (PDB 5HZG, where SMAX1 was absent), but the LRR17 loop was arranged differently in our ASK1MAX2 apo structure (Supplementary Fig

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Their findings contribute nuanced insight into the regional vulnerability of the brains antioxidant defense in the context of mood disorders (16)