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GLP-1 receptors in the brain The brain contains abundant GLP-1 receptors in key regions including the hippocampus, cerebral cortex, hypothalamus, thalamus, and globus pallidum 26

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Second, the use of DPP-4 inhibitors to prevent the proteolytic degradation of GLP-1 by the DPP-4 enzyme, thereby increasing native GLP-1 levels in the plasma

doi: 10.3389/fendo.2024.1431292

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The most common side effects are mild, including nausea, vomiting, bloating, constipation and diarrhea