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The G /GRK2 sequestration is an unlikely mechanism to explain heterologous desensitization in dorsal root ganglion cells because heterologous desensitization or short-term tolerance is not observed in the absence of -arrestin2 or blockade of p38 mitogen-activated protein kinases (Tan et al., 2009)

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At age 20, plasma levels average around 200 ng/mL

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