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A recent investigation has demonstrated that intracellular lactate accumulation under ischemic conditions can inactivate the AMPK/GPX4 axis to promote myocardial ferroptosis (98)

Providers should conduct thorough medical history reviews, discuss potential risks and benefits honestly, and obtain written informed consent

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While an advantage of their study was that it was in a clinical rather than experimental setting, one disadvantage was that they used only phenotype and not genotype to identify red-haired patients

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