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wustl.edu Cellular mechanisms to clear misfolded proteins, and therapies to minimize toxicity by stimulating degradation of misfolded proteins As a physician-scientist, David Perlmutter is internationally recognized for his research on alpha-1 antitrypsin deficiency (ATD), a genetic disorder in which accumulations of a misfolded protein can cause severe liver damage

Fifth, sex-specific analyses were not performed because of the limited sample size and the retrospective single-center design of this study

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Genetic abnormalities or secondary illnesses caused by excessive blood transfusions, dyserythropoietic syndromes, persistent haemolysis, or iron supplementation can cause iron metabolism issues, which can manifest as primary or secondary iron overload conditions

The regulatory status varies by country and jurisdiction