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Neumann et al., 2018

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After phase I and phase II, Tac is metabolized into at least 8 different products (21), potentially involved in mechanisms of Tac toxicity (22)

The article says leg cramps and muscle spasms are not routinely reported as primary side effects in semaglutide trials, where nausea, vomiting and gastrointestinal discomfort dominate the safety profile, and that musculoskeletal complaints typically occurred at rates similar to placebo

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