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Ozempic (semaglutide) 0.25 mg, 0.5 mg, 1 mg, and 2 mg injection pens, which are approved as treatments for Type 2 diabetes, will also be available for eligible patients based on individual clinical judgment

A key differentiating feature is the attachment of a C18 fatty acid via a spacer to Lys at the 26th position, facilitating strong binding to albumin and thereby significantly prolonging plasma half-life

The high-dose arm at 9 mg produced the 20% reduction

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Plasma total cholesterol (Thermo Fisher Scientific, Infinity Total Cholesterol Reagent, TR13421), triglycerides (total glycerol and triglycerides) (Thermo Fisher Scientific, Infinity Total Triglycerides Reagent, TT22421), non-esterified fatty acids (NEFA) (Invitrogen, non-esterified free fatty acids (NEFA/FFA) Colorimetric Assay Kit, Thermo Fisher Scientific, EEA017), AST (Thermo Fisher Scientific, EEA003) and ALT (Thermo Fisher Scientific, EEA001) were quantified using enzymatic kits according to the manufacturers protocols