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In adipocytes, NNMT inhibition elevates NAD and SAM and suppresses de novo lipogenesis in a concentration-dependent manner, consistent with on-target activity [13]
It has been speculated that oxidative stress as well as mitochondrial damage may act together in inducing neurodegeneration
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It modulates melanogenesis by inhibiting tyrosinase and shifting melanin synthesis from dark eumelanin to lighter phaeomelanin
J Exp Bot 75:25992603 Conn EE, Vennesland B (1951) Glutathione reductase in wheat germ
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