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B12 is known for its role in energy metabolism

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A third, recent study in JAMA Network Open , from August of 2025, analyzed data from 159,000 people with type 2 diabetes who took semaglutide or tirzepatide (Mounjaro, Zepbound)

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Side effects (if any): Noting severity and duration of any GI symptoms helps you decide whether to adjust escalation timing, consider dose splitting, or consult additional resources