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Proper eating habits also play a crucial role: Eat slowly and chew food thoroughly to aid digestion Avoid drinking through straws, which increases air swallowing Limit carbonated beverages that introduce additional gas Avoid talking whilst eating to reduce air intake Remain upright for 30-60 minutes after meals Avoid large or high-fat meals that slow digestion further Over-the-counter remedies may provide symptomatic relief

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The activity of sodium-glucose-co-transporter-2 (SGLT2) inhibitors induces a change in microbiome diversity, leading to increased GLP-1 production from bacterial-produced post-biotics, noticeably those of tryptophan metabolism [147]

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3.2 NTHi acquisition of host-derived haem-iron sources Despite the inherently low availability of haem-iron in the respiratory tract, NTHi is adept at scavenging a variety of host-derived haem-iron sources from intracellular and extracellular reservoirs, using a highly complex and redundant repertoire of haem acquisition systems ( Table 1 )

Mice were weighed twice per week