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Orlistat works by reducing fat absorption rather than affecting appetite hormones, but it's important to note that it commonly causes gastrointestinal side effects (including steatorrhoea and urgency) and is contraindicated in chronic malabsorption conditions and cholestasis

They can also help preserve muscle and improve insulin sensitivity

The goal isn't to push through indefinitely on a protocol that isn't working

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Avoid intense strength training or high-impact cardio during the first 4 weeks

Rybelsus (oral): Begin with 3 mg once daily for 30 days, then increase to 7 mg