(68), which reported that sweet taste receptor antagonism with lactisole reduced GLP-1 and PYY secretion but had no effect on CCK release, highlighting pathway-specific effects
Biol Psychiatry (2020) 87(9):797807
Preliminary data suggest that GLP-1RAs may be effective in the treatment of hypothalamic obesity, and the presence of GLP-1R in various regions of the hypothalamus and in other regions of the brain explains the potential effectiveness of GLP-1RAs even in cases of hypothalamic damage [16]
Wharton S, Calanna S, Davies M, Dicker D, Goldman B, Lingvay I, Mosenzon O, Rubino DM, Thomsen M, Wadden TA, Pedersen SD
One unanswered question is whether long-term use could lead to reduced responsiveness over time
It often means less drinking, especially when nausea, early fullness, or a changed taste for plain water gets in the way