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And in another clinical trial, injections of 15-mg doses of tirzepatide (the active ingredient in Eli Lilly's weight-loss injectable Zepbound) resulted in an average of about 21 percent body-weight reductions after 72 weeks

Discolouration of the rope may also occur, thus giving an early warning of the problem

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Particularlly, contractility of cardiac myocytes is significantly impaired[281, 282] together with a deficient compensatory hypertrophic response, following experimental aortic constriction[281]

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