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The time for metabolic health is now The obesity crisis has impacted the lives of millions globally, and the negative consequences of this condition can span from metabolic syndromes to heart disease, cancer and an increased stroke risk

doi: 10.1186/s12951-018-0392-8 116

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[DOI] [PubMed] [Google Scholar] Garca Muoz R, Izquierdo-Gil A, Muoz A, Roldan-Galiacho V, Rabasa P, Panizo C, 2014

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This effect exerted was found to be mediated by the subsequent activation of the PI3K/Akt/GSK3 signaling pathway, followed by the activation of IP3R in the endoplasmic reticulum that resulted in the elevation of intracytoplasmic Ca 2+ , which finally culminated in mitochondria-dependent apoptosis