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In those cases, the fix is often part mechanical, part medical, and not just try another pill. This is one reason LL-37 is discussed in stubborn sinus and airway issues, where biofilms can play a part

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Henriques P, Bicker J, Carona A, Miranda M, Vitorino C et al (2023) Amorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics