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Human clinical trials are limited, and BPC-157 has not completed the rigorous FDA approval process required to be marketed as a drug for human use

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3 and 4) Natural products protective and therapeutic effects on hearing loss are thought to be the result of molecular pathways that target multiple pathophysiological states, including inflammation, pro- and apoptotic mediators, oxidative damage, and impaired survival regulation

This tells us two things

Although the liver is recognised as a major site of metformin pharmacodynamics, recent evidence also implicates the gut as an important site of action

Moreover, -MSH and its derivatives, like KPV, have garnered research interest for their activity in wound healing, particularly in minimizing scar formation and fostering a more regenerative healing process