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Kenji Hara received Grant-in-Aid for Scientific Research (KAKENHI), Grant Number 23K10720 from Japan Society for the Promotion of Science (JSPS)

Weight patterns over several weeks, rather than short-term changes

This becomes especially pertinent when considering medications like Wegovy, a powerful agent in the fight against obesity, and gabapentin, widely used for neurological conditions and pain management

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Even large trials/registries may lack power for small absolute risk increases Follow-up duration: Most studies provide 2-5 years observationsufficient for short-term safety, potentially insufficient for very long latency Histologic subtype adjudication often incomplete