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these interactions help regulate DNA replication 5,6,7 and maintain mRNA stability 8 in the rat brain

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This reveals that the ensuing lipid remodeling is important for ferroptosis protection

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Here we unveiled an essential role of E3 ligase SMAD ubiquitylation regulatory factor 1 (Smurf1)-mediated phosphoinositide-dependent protein kinase 1 (PDK1) neddylation in PI3KAkt signaling and tumorigenesis

It is also vital for glucose production in ruminants, which is essential to meet the high energy demands of growth and lactation