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Extended exposure to ibuprofen in a semaglutide-slowed stomach increases the risk of gastric irritation, ulcers, and gastrointestinal bleeding

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These observations are not officially documented as a direct effect of tirzepatide in clinical trials, but several plausible mechanisms may explain this phenomenon

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This mechanism is well-documented in GLP-1 clinical trials and improves as your body adapts to your dose over weeks