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Melanocyte-stimulating hormone is a derivative of the precursor proopiomelanocortin, an agonist on the melanocortin-1 receptor that promotes formation of eumelanin

4 In TRANSCEND-T2D-1, Lillys first Phase 3 trial in adults with type 2 diabetes (537 participants, 40 weeks), retatrutide produced 16.8% weight loss at the 12 mg dose

The mechanism may be related to the decrease of forkhead-box class O (FOXO) transcription factor expression in chondrocytes, thus weakening the cell's resistance to oxidative stress [41]

The average patient loses 5-7% of their starting weight within the first three months, with losses often accelerating as medication dosages are optimized

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