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When serum ferritin levels elevated, it causes exacerbated inflammatory conditions and induces oxidative damage and ferroptosis, along with the decrease in GSH levels (which functions as an oxidative stress regulator), creating a series of reactions that resulted in multiple organ failure, pulmonary injury, and reduced lung capacity in the study Group A

International journal of molecular sciences , 25 (21), 11651

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However, CF, PCD, and NCFB are rarer with incidences ranging from 1 in 20,000 for PCD, between 50 and 1,000 in 100,000 for NCFB, and around 160,000 individuals with CF worldwide (Nigro et al., 2024

USA 102 (31), 1107011075