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These studies suggest that deficiencies in GH and IGF-I contribute to a functional decline in senescent rats, whereas augmentation of GH or IGF-I improves cognitive function, increases glucose utilization throughout the brain, increases cortical vascularity, and ameliorates age-related decline in hippocampal neurogenesis
doi: 10.1210/jc.2012-3856 224 de BonoJSPiulatsJMPandhaHSPetrylakDPSaadFAparicioLMet al
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