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The most common side effects are gastrointestinal nausea, diarrhea, constipation which often improve over time

Excess body weight increases knee joint loading, alters gait mechanics, and accelerates degeneration of the osteochondral unit ( From a clinical standpoint, obesity-related KOA also appears to represent a distinct and therapeutically challenging phenotype

By acting as a carrier and regulator of bioavailable copper, GHK-Cu plays a role in maintaining metal homeostasis and influencing downstream pathways linked to cellular growth, differentiation, and tissue remodelling