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Moreover, Poor oral exposure limits interpretation of capsule claims

Joint Bone Spine 2010;77:131-4.

People who have undergone some sort of trauma to the intestines including a gastric bypass or intestinal surgery can be susceptible to vitamin B12 deficiencies since they may have less cells present to produce the protein to which the B12 can attach, resulting in a decreased ability to absorb B12 into the bloodstream

Retrieved 10 January 2020

Second: the short plasma half-life (~30 min) was insufficient, by the time the fragment circulating in the blood was supposed to act, it had already been metabolized

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