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The 4 mg dose produced 11% weight loss, still clinically meaningful but notably lower than the maximum dose

This is especially important during GLP-1-assisted weight loss

Pathophysiology of Facial Volume Loss with GLP-1 Medications The use of semaglutide and similar compounds leads to a reduction in overall body fat , including subcutaneous facial fat

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The potential antidepressant effect of antidiabetic agents: New insights from a pharmacovigilance study based on data from the reporting system databases FAERS and VigiBase

Here is a summary of results across the major trials