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*L-Carnitine:* - *Fat Metabolism*: L-carnitine plays a crucial role in the transportation of fatty acids into the mitochondria of cells, where they are oxidized and used as a source of energy

In preclinical models, combining GIP and GLP-1 activation produced greater weight reduction than either receptor in isolation ( Jastreboff et al., NEJM, 2022 )

10.1016/s0304-3835(97)00300-5 31 LuoL.ChenH.TrushM

Mitochondrial dysfunction and oxidative stress constitute central mechanisms in MASH pathogenesis, with MASLD progression closely linked to mitochondrial impairment (69)

Some similarities and differences in gut microbiota modulation could be observed, while flaxseed oil showed different health-promoting effects in animal experiments

Reduced insulin resistance : By reducing body weight and fat mass, Wegovy helps improve insulin sensitivity, making it easier for the body to use glucose efficiently