1 (download XLSX Statistical Source Data
Gupta will evaluate your medical history, metabolism, weight loss goals, and previous treatment experiences to determine whether semaglutide or tirzepatide is the most appropriate option for your needs
But success depends on more than just weight loss
For example, PEGylated PYY(3-36) has a half-life extended to 24 hours and does not show toxicity in a rabbit model (157)
: JAMA Psychiatry study highlights (semaglutide in schizophrenia spectrum disorders): Studied adults with schizophrenia spectrum disorders treated with clozapine or olanzapine, two antipsychotics strongly linked to weight gain and metabolic syndrome Participants were randomized to receive semaglutide (GLP-1 receptor agonist) vs placebo, in addition to usual psychiatric care Significant weight loss was observed in the semaglutide group compared with placebo Improved glycemic control including reductions in HbA1c and fasting glucose, even in early metabolic dysregulation Beneficial effects seen early, suggesting potential for prevention of diabetes rather than late treatment Semaglutide was generally well tolerated, with no worsening of psychotic symptoms Addresses a major unmet need, people with serious mental illness die earlier largely due to cardiometabolic disease Supports the role of GLP-1 receptor agonists as an adjunct treatment to mitigate antipsychotic-induced metabolic harm Bottom line: A promising strategy to reduce weight, diabetes risk, and long-term cardiovascular mortality in patients on high-risk antipsychotics
In making the case with her boss and the insurer, she cited herself as an example: By taking the medicines, she now needs far fewer doctor's appointments, physical therapy and medications to manage various ailments associated with obesity
